Kendrick's three-run homer in the fourth made it 6-0. Iannetta walked and Erick Aybar reached base on an infield single. Kendrick then cleared the wall in left.
Wells' solo homer to left in the fifth gave the Angels a seven-run cushion.
New York left more men on base in the sixth. With men on second and third and two outs, Jeter flied out.
Hughes fell to 3-2 lifetime versus the Angels...New York went 1-for-11 with runners in scoring position and stranded 10, while LA went 1-for-8 with RISP and left six men on...Jeter had two hits.
Chris Volstad (0-1) gave up four runs -- three earned -- on six hits while striking out four to extend his winless streak to 13 games. He has not earned a win since July 10, 2011, recording six losses and seven no-decisions in that span.
Starlin Castro knocked in the lone run for Chicago, which had won its previous two.
The Cubs got on the board in the sixth when David DeJesus led off with a walk, moved to second on Darwin Barney's groundout to short and came home on a Castro base hit to center.
Alfonso Soriano then singled to place runners on the corners with one out, but Lynn was replaced on the mound by J.C. Romero, who struck out Ian Stewart and Bryan LaHair to keep it a 4-1 game.
Chicago had a chance to cut into the lead in the eighth when the Cubs put runners on second and third with one out on DeJesus' single and a double by Castro, but Fernando Salas fanned Soriano before Marc Rzepczynski took the bump and induced a fly out to center by Stewart to end the threat.
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